NFL Betting: Best Lines For Week 10 Look Toward Bills, Cardinals

  • Week 10 of the NFL features some decisive matchups, like the Buffalo Bills as the -2.0 underdog against the Arizona Cardinals.
  • Other odds include the Miami Dolphins as slight favorites (-145 odds) over the Los Angeles Chargers, and the Seattle Seahawks underdogs to the Los Angeles Rams.

LAS VEGAS – As the NFL moves into the later realms of the season, temperatures begin to fall while the competition is only heating up across the country.

Many teams are locked into divisional races at this point, while others are desperate for wins to fuel a playoff push.

Those looking to bet on Week 10 action have a few different games that stand out on the major online sportsbooks.

NFL Week 10 – 4:05 p.m. EST

  • Buffalo Bills +110
  • Arizona Cardinals -130
  • Spread: ARI -2.0
  • O/U: 56.0

The Buffalo Bills earned a tremendous win over the Seattle Seahawks last week to get to 7-2 on the season. The Bills were able to cover the spread in that game, but are still just 4-5 ATS on the season. The Bills are the underdog to Kyler Murray and the Cardinals on the road, who are 5-3 ATS this season.

Murray led the Cardinals offense to another high-scoring effort last week, but fell just short at the hands of Tua Tagovailoa’s Miami Dolphins. The Cardinals should be able to score on the Bills defense, but might have trouble stopping Josh Allen much like they struggled to stop Tua.

Edge: Bills +2.0

NFL Week 10 – 4:05 p.m. EST

  • Los Angeles Chargers +125
  • Miami Dolphins -145
  • Spread: MIA -3.0
  • O/U: 48.0

Speaking of Tua Tagovailoa, the rookie quarterback led his Dolphins to a dramatic win over the Cardinals last week. Down by a touchdown late in the second half, Tua led the Dolphins on a 93-yard drive to tie the game in which he completed five of five passes for 53 yards and scampered for an additional 23 yard first-down run.

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It was peak Tua at his best on Sunday, leaving many Dolphins fans feeling better about the decision to start the rookie over Ryan Fitzpatrick. The Dolphins now head into a matchup with the Chargers in a battle of Rookie Of The Year candidates.

While the Chargers have looked decent under Justin Herbert, the Dolphins defense has seriously stepped up the last few weeks. If the Dolphins defense continues to play well and Tua is able to make passes, Miami should be too much for the Bolts.

Edge: Miami -3.0

NFL Week 10 – 4:25 p.m. EST

  • Seattle Seahawks +105
  • Los Angeles Rams -125
  • Spread: LAR -1.5
  • O/U: 55.5

Following their loss to the Bills, the Seahawks now find themselves as underdogs against the Los Angeles Rams. Seattle is in an interesting position this season, as the team has one of the best scoring offenses in the league to compliment one of the worst scoring defenses in the league.

This was on full display against Buffalo. Russell Wilson threw for 390 yards and two touchdowns to score 34 points, but the Seattle defense gave up 44 points and allowed Josh Allen to throw for 415 yards and three touchdowns.

If this is the format for the Seahawks going forward, teams like the Rams that have strong defenses and capable quarterbacks should continue to feast on Seattle, despite Wilson’s MVP-level play. NFL bettors should take advantage of these matchups going forward.

Edge: Rams -1.5