Week 10 CFB Betting Odds Breakdown: 3 Top-25 Games

  • Clemson is favored to beat Notre Dame with -200 odds.
  • Georgia has -155 odds to defeat Florida.
  • Michigan is seen as the favorite to beat Indiana.

CLEMSON, S.C.College football bettors have a big Week 10 of college football action ahead of them as there are some key matchups in the top 25.

These key matchups include a primetime matchup in the ACC between Clemson and Notre Dame, an SEC showdown between Georgia and Florida and a Big 10 clash between Michigan and Indiana.

Clemson (1) Vs. Notre Dame (4), 7:30 p.m. EST

  • Moneyline: Clemson (-200) vs. Notre Dame (+170
  • Total: 50.5 Points
  • Spread: Clemson -5.0

Starting with the primetime game between the top-ranked Clemson and number 4 Notre Dame, online sportsbooks are seeing Clemson as the favorite to win despite Trevor Lawrence not playing.

Lawrence is still in COVID-19 protocols after testing positive.

Clemson is still seen as the favorite, being the number one team in the country with D.J. Uiagalelei under center. Uiagalelei had a nice game in his first start as he went for 342 yards and two touchdowns and a rushing touchdown as well.

With that said, this is only going to be the fifth meeting between the two powerhouse teams and Clemson holds the advantage 3-1 in their first four games. As for some betting trends for the two teams, in their last 13 games as a road favorite, Clemson has gone 11-2 against the spread.

However, Notre Dame has gone 5-0 against the spread in their last five games as a home underdog, making this college football bet quite a tough decision.

Georgia (5) Vs. Florida (8), 3:30 p.m. EST

  • Moneyline: Georgia (-155) vs. Florida (+135)
  • Total: 52.5 Points
  • Spread: Georgia -3.5

In the SEC, a showdown rivalry between Georgia and Florida is on the horizon. This will be the 98th meeting between the two teams and Georgia holds the advantage right now 52-43 with two ties in the series.

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Georgia has also won the last three meetings as well.

Both teams have one loss on the season, but being that Georgia’s only loss came at the hands of Alabama who are ranked 2 in the country and Florida’s came against a then 21 ranked Texas A&M could be why Georgia’s college football odds are favored.

Looking at trends between the two ahead of their clash, in their last six meetings, the road team has gone 5-1 against the spread.

Also, over the last five meetings of the "World's Largest Outdoor Cocktail Party", the favorite has gone 5-0 against the spread.

Michigan (23) Vs. Indiana (13)

  • Moneyline: Michigan (-155) vs. Indiana (+135)
  • Total: 54.5 Points
  • Spread: Michigan -3.0

In the Big 10, Michigan and Indiana will face off in a top 25 clash which will be their 69th all-time meeting between the two. Michigan holds a huge advantage in the series as they have won 59 games to Indiana’s 9 which includes the current 24 game win streak that they are on against them as well.

As for some trends on the matchup, Michigan has gone 1-3-1 against the spread in their last five meetings. Also, the underdog going into the game has gone 3-1-1 against the spread in their last five meetings as well.

Looking at the total for points, the over has gone 4-0 in their last four meetings in Indiana.