- The 49ers are the only remaining undefeated team in the NFC.
- Kyler Murray, the No. 1 pick in the 2019 NFL Draft, will face-off against the No. 2 pick, Nick Bosa.
- The Cardinals are on an eight-game winning streak against the 49ers.
GLENDALE, Ariz. – A special Halloween edition of Thursday Night Football gives us an NFC West matchup between the undefeated San Francisco 49ers (7-0) and the Arizona Cardinals (3-4-1).
At USA online sportsbooks, the 49ers are 10.5-point favorites to remain undefeated on the road against the Arizona Cardinals. Surprisingly, both teams have performed well ATS this season as the 49ers are 5-2 and the Cardinals are 5-3.
The 49ers should be able to cover the 10.5-point spread comfortably in this matchup as they look to go on an eight-game winning streak against the Cardinals.
San Francisco has simply been on a roll this season despite their quarterback Jimmy Garoppolo struggling at times. In his return from an ACL injury a year ago, Garoppolo has thrown for 1,489 yards, nine touchdowns, and seven interceptions this season.
Arizona’s running backs have been plagued with injuries as David Johnson is a game-time decision and Chase Edmonds will miss this game with a hamstring injury.
These injuries are why the Cardinals made a trade for Miami Dolphins running back Kenyan Drake before Tuesday’s trade deadline. Drake is expected to get a chunk of the carries for Arizona running backs tonight and will have a tough matchup in his first game as a Cardinal against the 49ers rush defense.
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With the 49ers boasting one of the NFL’s stingiest defenses, it’s no surprise the Over/Under total for this game is set at 43. In four of the last five meetings between the 49ers-Cardinals, the total has gone Under. With the 49ers defense only allowing an average of 11 points per game, the Under should be a comfortable bet tonight.
TNF Prop Bet To Consider
The Cardinals offensive line has been atrocious this season as they’ve allowed rookie quarterback Kyler Murray to get sacked 26 times, which is third-most in the NFL.
The 49ers defense will have a big game tonight and will be after Murray all night. Although the Cardinals have not turned the ball over once in its last four games, this will be the game that streak ends.
This makes the “Will a Special Teams or Defensive TD be scored?” an intriguing bet to look at tonight. With “Yes” odds at +220 and the “No” odds -300, take the "Yes". The 49ers defense has forced the third-most turnovers in the NFL this season. Kickoff for the 49ers-Cardinals game is scheduled for 8:20 p.m. EST. The game will be broadcast by FOX Sports and NFL Network.
As a professional sports writer, Robert has written for outlets such as the FAMUAN and other sports-centric platforms. He focuses mainly on NFL and NBA betting, though he keeps tabs on every major sport.