NFL Week 1 Betting Guide: Los Angeles Rams Vs. Buffalo Bills

  • The Buffalo Bills have -140 odds and a 2.5-point spread to beat the Los Angeles Rams in Week 1.
  • The Bills are taking 83% of the handle bet on the moneyline in Week 1.
  • Defending Super Bowl champions are 18-3 S/U in Week 1.

LOS ANGELES – The 2022 NFL season will kick off with a powerhouse matchup between the defending Super Bowl champions, the Los Angeles Rams, and the preseason Super Bowl favorites, the Buffalo Bills (+550). The Bills odds going into this Thursday Night Football opener are favored by oddsmakers and the public.

Buffalo Bills Vs. Los Angeles Rams

  • Moneyline: Bills (-140) vs. Rams (+120)
  • Spread: Bills -2.5 (-110)
  • Total: 53 Points

On the moneyline, online sportsbooks show Buffalo getting 58% of the total bets, however, sharps are laying heavy action at 83% of the betting handle. On the 53-point total, it has seen similar action on both sides with the over and under each taking 50% of total bets while the handle is split 60%/40% in favor of the over.

As for the spread, the public has had a heavy impact on the line having helped move it from a 1-point spread in favor of the Rams at first opening to the 2.5 points it’s at now in favor of Buffalo. This comes as the Bills are seeing 67% of total Super Bowl bets and 89% of the money.

Trends To Keep an Eye On

While the public has been heavily on the Bills, defending Super Bowl champions have been dominant over the last 21 years in Week 1. They are 18-3 S/U and 13-6-2 ATS over that span. However, that is it for trends favoring the Rams in Week 1.

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Buffalo has gone 12-5 ATS in their last 17 Week 1 matchups and are 5-2 ATS in their last seven games playing in September. In their recent matchups with the Rams, they’ve been hot as well going 4-1 ATS in the last five meetings.

Something else to keep in mind is that with this game being a Thursday Night Football matchup, it could have an effect as well. So far in Josh Allen’s young career, he has gone 2-0 on TNF while Matthew Stafford has gone 5-7 overall and 1-4 in his last four Thursday Night games.